Santa Croce Vacations from $886

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Your Santa Croce Vacation

Discover the best that Santa Croce offers with a Santa Croce vacation package. From its culture to every other thing that makes it special, this neighborhood will charm you from beginning to end. When it's time to take in the sights, you'll find loads of popular attractions nearby including Rialto Bridge, St. Marks Basilica and St. Marks Square. Visit one, two or more during your trip to Santa Croce. Don't just dream it — do it! Lock in your ideal Santa Croce vacation with Expedia and experience travel your way.

The Latest Santa Croce Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Bisanzio

Hotel Bisanzio

Castello
$886
per person
Dec 6 - Dec 12
found 23 hours ago
Roundtrip non-stop flight included
New York (JFK) to Venice (VCE)
9/10 Wonderful! (1,003 reviews)
The hotel has a great location if you’re looking for St Mark’s square proximity. Breakfast was nice. Just be aware the hotel has an annex and you may end up there. You leave the hotel, go down a short alley, through a small courtyard to their annex building. The room was ok but we would have preferred the main building. Breakfast is in the real hotel. Also, for those who care, English language tv is scarce and inconsistent.

Reviewed on Sep 23, 2026

Palazzo Veneziano

Palazzo Veneziano

Dorsoduro
$1,159
per person
Dec 6 - Dec 12
found 23 hours ago
Roundtrip non-stop flight included
New York (JFK) to Venice (VCE)
9.6/10 Exceptional! (1,197 reviews)
Ca' Sagredo

Ca' Sagredo

Cannaregio
$1,282
per person
Nov 20 - Nov 24
found 24 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Venice (VCE)
9.2/10 Wonderful! (534 reviews)
Good location by the water bus stop on the Grand Canal and thankfully a bit away from the crowds of St. Marco district, which is easy 10-minute walk away. Big room, marble-everywhere bathroom, comfortable bed, strong AC, BUT the carpet in room 101 should have been replaced 10 years ago. Guessing it used be white, but now it is gray-ish and covered in dark stains all over. Oddly, a porter entered the room "to check the minibar inventory" while we were in the room resting in the afternoon. Why the inventory count was not done during the cleaning earlier in the day??... Not a 5-star hotel category.

Reviewed on Sep 21, 2026

Palazzo Dei Fiori By Room Mate

Palazzo Dei Fiori By Room Mate

Venice City Center
$1,664
per person
Nov 6 - Nov 10
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Venice (VCE)
10/10 Exceptional! (91 reviews)
Hotel San Moisè

Hotel San Moisè

Venice City Center
$1,780
per person
Nov 6 - Nov 10
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Venice (VCE)
7.8/10 Good! (753 reviews)
Great Location but room and bed were challenging

Reviewed on Sep 23, 2026

Where to stay in Santa Croce

Find the best Santa Croce areas and neighborhoods for the activities you enjoy most. Learn more about Santa Croce
A historic building with a dome and bell tower by the water.

Venice City Center

5 out of top 10 points of interest in this area

Discover an abundance of architectural monuments and great art by grandmasters in the heart of an Italian city built on water.

Find hotels in Venice City Center
A canal with gondolas, people walking on the steps, and storefronts with signs like "Giorgio Armani".

San Marco

In the heart of Venice, this densely built area boasts iconic attractions like St Mark's Square, Saint Mark's Basilica, and the Doge's Palace. Find numerous hotels, banks, and high-end shops amid the bustling tourist scene.

Find hotels in San Marco
A canal in Venice with colorful buildings and a bridge.

Cannaregio

Explore historic churches like Santa Maria di Nazareth and Santa Maria dei Miracoli, or admire stunning palazzos such as Ca' d'Oro and Ca' Vendramin Calergi. Enjoy morning markets, local shops, and quaint cafés in this residential, peaceful district.

Find hotels in Cannaregio
A canal with boats docked, historic buildings, and a clear sky.

San Polo

Smallest and most central sestiere, San Polo boasts churches in the west, palaces in the east, and iconic attractions like Rialto Bridge and Scuola Grande di San Rocco.

Find hotels in San Polo
A canal with a bridge, buildings with blue shutters, and a sign in Italian.

Dorsoduro

Boasting the highest land areas in Venice, this sestiere features the stunning Basilica of Santa Maria della Salute and the picturesque Zattere quay. Easily connect to San Marco via Ponte dell'Accademia.

Find hotels in Dorsoduro

Santa Croce Hotel Deals

Hotel Antiche Figure

Hotel Antiche Figure

Santa Croce 687 Venice VE
$369 nightly
$414 total
Sep 27 - Sep 28
Total with taxes and fees
9.8/10 Exceptional! (1,005 reviews)
"The hotel staff was amazingly helpful and courteous! This hotel would have definitely gotten a 10 out of 10 if it would have had an elevator to the rooms and a remote control that worked with the TV (my guess is that the original samsung remote was lost and was replaced with a generic remote that ..."

Reviewed on Sep 22, 2026

Hotel Antiche Figure
Hotel Canal Grande

Hotel Canal Grande

Santa Croce 932 Venice VE
$317 nightly
$358 total
Oct 25 - Oct 26
Total with taxes and fees
Hotel Canal Grande
Santa Chiara Hotel

Santa Chiara Hotel

Santa Croce 548 Venice VE
$308 nightly
$349 total
Oct 25 - Oct 26
Total with taxes and fees
9.4/10 Exceptional! (403 reviews)
"Wonderful staff. Great location right by vaporetto stop. Quiet. Lovely views. Breakfast was good. Very clean."

Reviewed on Sep 19, 2026

Santa Chiara Hotel
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Stay near popular Santa Croce attractions

A bridge over a canal with buildings and a green dome in the background.

Piazzale Roma

8.6/10 (9,106 reviews)
You can learn about the local history of Venice during your trip to a top site like Piazzale Roma. Stroll along the marina or visit the stunning cathedral in the area.
See properties
A narrow canal in Venice, Italy, flanked by historic buildings with arched windows and balconies.

Ca'Pesaro

6.0/10 (1 review)
You can browse the exhibits at Ca'Pesaro, a museum with a storied past, during your trip to Venice. Stroll along the marina or visit the stunning cathedral in the area.
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A historic building with a row of arches and a series of pointed towers.

Venetian Museum of Natural History

9.0/10 (2 reviews)
You can study the exhibits at Venetian Museum of Natural History, a museum with a storied past, during your trip to Venice. Stroll along the area's marina or experience its acclaimed art scene.
See properties
A historic building with arched windows and a domed structure in the background.

Fondaco dei Turchi

9.4/10 (10 reviews)
You can browse the exhibits at Fondaco dei Turchi, a museum with a storied past, during your trip to Venice. Stroll along the marina or visit the churches in the area.
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A calm water body reflecting buildings, including a modern white structure and a yellow building.

Fondazione Prada

You can browse the exhibits at Fondazione Prada, a museum with a storied past, during your trip to Venice. Visit the area's stunning cathedral or amble around its marina.
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Ca' Pesaro Galleria Internazionale d'Arte Moderna

6.0/10 (1 review)
You can browse the exhibits at Ca' Pesaro Galleria Internazionale d'Arte Moderna, a museum with a story of its own, during your travels to Venice. Discover the area's fascinating museums and stunning cathedral.
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San Stae

8.0/10 (1 review)
Find out about the history of Venice when you take a trip to San Stae. Stroll along the area's marina or experience its acclaimed art scene.
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San Giacomo dall'Orio

Find out about the history of Venice when you spend time at San Giacomo dall'Orio. Experience the area's acclaimed art scene and fascinating museums.
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Things to do

Sunset Cruise with Aperitivo & Lagoon Views

Sunset Cruise with Aperitivo & Lagoon Views

$34
per adult
Sunset Cruise with Aperitivo & Lagoon Views
Sidewalk flanked by colorful buildings in Burano

Murano & Burano Tour

$41
per adult
90% of travellers recommend
Murano & Burano Tour
Taste of Venice: Local Tapas Tastings & Wine Tour

Venice Small Group Food Tour: Venetian Tapas, Wine, Spritz & Gondola Ride

$92
per adult
96% of travellers recommend
Venice Small Group Food Tour: Venetian Tapas, Wine, Spritz & Gondola Ride
See all activities in Venice
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.